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The Company has elected to adopt the practical expedient to measure its defined benefit plans.
Additionally, the dose response curve was bell-shaped.
In 2002, Amgen revised package inserts for darbepoetin and Epogen to include recommendations that hemodialysis patients with antibody-mediated PRCA not be given other epoetins.
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The benefit is also available to Additional Card Members on eligible Consumer and Business Card accounts.
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Please, keep in mind that the time of delivery specified here is the estimated delivery time which is true for most cases, but cannot be guaranteed due to the probability of force majeure events described below.
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Despite the importance of rapidly controlling the increasing number of new cases of epoetin-associated PRCA and sharing emerging safety findings, representatives from each of the three manufacturers attended no joint meetings.
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Kidney failure can come on acutely or occur gradually over weeks or months.
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Data were selected for analysis using an evidence hierarchy and quantitatively analyzed to assess statistical homogeneity.
Since 2005, ESA use among nondialysis CKD patients declined from 60 to 46%, and mean monthly dose among nondialysis CKD patients who received ESAs declined 25%, with the largest decline beginning in 2007.
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People who need to receive the medication into a vein will need to have the medication administered by a doctor or nurse.
Gonzalez said that the litigation process and its intellectual property estate, including 70 ancillary patents covering the formulation, manufacture and dosage, will protect Humira from biosimilar entry until 2022.
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There are several options for inducing remission of PRCA, but many patients with acquired PRCA require immunosuppressive therapy to maintain remissions.
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If the medicine has changed color, or if you see specks (particles) floating in it, do not use it.
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Naravno, kao olaksavajua okolnost je cinjenica da nije samo dovoljna dugotrajna ekspozicija virusa hepatitsa B ili ciroza nastala iz ovog oboljenja, ve su potrebni i drugi faktori: genetski, nacin ishrane, hemijski kancerogeni, npr, iz radne sredine, imunoloski i hormonski utjecaji, i drugi.
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Generic drugs contain the same active ingredients as the original brand drugs.
Your doctor may also suggest clinical trials that are studying new ways to treat this type of recurrent disease.
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ESAs, target Hb values can be maintained and a dose saving can be achieved, but a similar level of evidence has not been reported in cancer patients.
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Epo has potentially beneficial effects on the endothelium including anti-apoptotic, mitogenic and angiogenic activities.
Reilly: A potent erythropoietin-mimicking human antibody interacts through a novel binding site.
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Even after a biosimilar receives approval, pharmacovigilance studies will need to be implemented to mitigate any additional unknown potential risks associated with biosimilars relative to the innovator drug.
Many studies used another ESA as an active control.
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Measures are described which should facilitate the recognition of medical prescriptions of biologicals and, thus, also of biosimilars issued in another Member State.
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The primary endpoint was reached by 98% of the subjects in the Mircera arm and 96% of the subjects in the Darbepoetin alfa arm.
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The fair values for the sales and earnings per share goals of each performance share unit were estimated on the date of grant using the fair market value of the shares at the time of the award, discounted for dividends, which are not paid on the performance share units during the vesting period.
Other epoetin products or darbepoetin products have not undergone formulation changes.
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Vasiljevi1 1 Institut za kardiovaskularne bolesti, Klinicki Centar Srbije, Beograd, 2 Institut za ginekologiju i akuserstvo, Klinicki Centar Srbije, Beograd, 3 Institut za transfuziju krvi Srbije, Beograd, 4 Institut za molekularnu genetiku i geneticki inzenjering, Beograd, 5 Urgentni Centar, Klinicki Centar Srbije Pluni tromboembolizam je jedan od vodeih uzroka mortaliteta u trudnoi (sa incidencijom 1 na 1000-3000 porodjaja).
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In May 1977 Extra corporeal Medical Specialties, a manufacturer of kidney dialysis and intravenous treatment products, became part of the corporation.
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The original manufacturer uses a brand name whereas a generic drug is usually called by the name of the active ingredient.
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Early Intervention with epoetin alfa during platinum-based chemotherapy: an analysis of quality-of-life results of a multicenter, randomized, controlled trial compared with population normative data.
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