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For the primary analysis, the incidence rate ratio was estimated for current use of pramipexole compared with the reference category of current use of other dopamine agonists.

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Using several clinical extrapyramidal features (resting tremor, rigidity, bradykinesia, postural instability, and freezing) the clinician can confidently say that a patient has definite parkinsonism if any 2 of the 5 features are present, with 1 of the 2 being tremor or bradykinesia.

Although no gender-related differences were observed in Parkinson's disease patients.

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Adjusted for current use of other dopamine agonists, other anti-parkinsonian drugs and selected.

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The disorders have much in common, including poor sleep habits, twitching, and the need to get up suddenly and walk about frequently.

He doesn't have a problem during the day.

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Eighty-five percent of RLS patients either have difficulty falling asleep or wake several times during the night, and almost half experience daytime or sleepiness.

In the brain of a Parkinson disease patient on the right, loss of pigmented substantia nigra due to depopulation of pigmented neurons is observed.

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While these complications may resolve when the drug is discontinued, complete resolution does not always occur.

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The choice of drug depends on the impact of improving motor disability (better with levodopa) compared with the risk of motor complications (more common in younger patients) and neuropsychiatric complications (more common in older and cognitively impaired patients; greater with agonists).

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Note that neither of these conditions can be cured using pramipexole.

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Parkinson's disease had a mean disease duration of 2 years, limited or no prior exposure to levodopa (generally none in the preceding 6 months), and were not experiencing the "on-off" phenomenon and dyskinesia characteristic of later stages of the disease.

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Currently, the recommendation for use of entacapone is limited to patients who are experiencing a wearing off of treatment efficacy when taking combined levodopa and carbidopa.

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RLS, and being a surgeon, I am sure he knew very little about RLS.

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Some doctors recommend regular use of dopamine receptor agonists for patients who experience nightly symptoms, and L-dopa for those whose symptoms occur only occasionally.

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Although levodopa helps at least three-quarters of parkinsonian cases, not all symptoms respond equally to the drug.

The condition may be associated with various psychiatric disorders, probably as a form of extrapyramidal hyperkinesis.

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Restless Leg Syndrome or “Restless Legs Syndrome” (RLS) is a problem that up to 10% of the US population experiences that causes a strong urge to move your legs.

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