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Journal of the American Medical Association study cited above) included men who did not undergo further treatment after biochemical recurrence occurred.
Adolescent Health Care chapter on breast concerns in adolescents, which states regarding breast hypertrophy: “Preferably, treatment should be deferred until breast growth has been completed.
Androgen-independent prostate cancer is a heterogeneous group of diseases: lessons from a rapid autopsy program.
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Levofloxacin and other fluoroquinolones have also been widely used for the treatment of uncomplicated community-acquired respiratory and urinary tract infections, indications for which major medical societies generally recommend the use of older, narrower spectrum drugs to avoid fluoroquinolone resistance development.
For example, one small but often-cited study, published in 1999 in the New England Journal of Medicine, found that 77% of men who had prostate cancer with lymph node metastases and chose to undergo hormone therapy were still alive and had no recurrent disease roughly seven years later, as compared with only 18% of men who decided to forgo hormone treatment until the cancer spread to bones or lungs.
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Use of neoadjuvant androgen deprivation therapy in clinically localized prostate cancer.
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Update on systemic therapy for advance prostate cancer.
During the mid-1990s, a new movement to control costs developed in the American healthcare marketplace: disease management.
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Insomnia, drowsiness, dry mouth, emotional instability, swelling of feet or lower legs, flu syndrome, high blood pressure, and hyperglycaemia, are also associated with taking synthetic hormones.
However, SRC-1 did not stimulate AR activity in the absence of ligand or in the presence of bicalutamide.
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They are used in androgen ablation therapy in combination with medical or surgical castration.
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Then, I recommend measuring the PSA every 3 months.
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The two treatment groups were well balanced in terms of patient demography and baseline disease characteristics ().
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If the cancer has spread, palliative treatment can improve the patient's quality of life by controlling the symptoms and complication; however, palliative treatment cannot cure the disease.
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Testosterone replacement for hypogonadal men can be beneficial, but longstanding fibrotic gynaecomastia is unlikely to respond.
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External beam radiotherapy has been utilized for the treatment of prostate cancer since the 1930s, with the radiation source at that time being low-energy orthovoltage equipment.
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Update on idiopathic hirsutism: diagnosis and treatment".
The drug works by preventing the actions of male hormones known as androgens in the body.
In these cases, your doctor may want to change the dose, or other precautions may be necessary.
In patients with large prostates, NAD therapy may facilitate resection by reducing prostate volume, creating more space for the surgeon to operate.
An abbreviation for a chemotherapy combination used to treat ovarian and testicular germ cell tumors.
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This is particularly important for someone with spine metastases, because a bone fracture or extension of the cancer into the spinal cord area could lead to impaired mobility and even paralysis.
In the guideline statements, the Panel selected the term "should" when the results of one or more RCTs do apply to the patient with clinical stage T1 to T2N0M0 disease and the term "may" when the results of one or more RCTs may apply to this patient population.
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Hormones are chemical substances that are produced by glands in the body, which enter the bloodstream and cause effects in other tissues.
Some Ayurvedic remedies contain harmful heavy metals such as lead or zinc.
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Residual tissue androgens are implicated in driving the majority of mechanisms whereby persistent AR-mediated signaling drives castration resistant disease.
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The most common types include: (1) incisional biopsy, in which only a sample of tissue is removed; (2) excisional biopsy, in which an entire lump or suspicious area is removed; and (3) needle biopsy, in which a sample of tissue or fluid is removed with a needle.
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Secondary endpoints included time to treatment failure, time to progression, survival, quality of life (QoL), time to PSA normalization, and the incidence of adverse events and adverse drug reactions.
The test measures the levels of this genetic fragment and another genetic marker (PCA3) in urine which are detectable at high levels in men who have prostate cancer.
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In another study with about half the men with very early-stage cancer, there was no survival advantage for surgical treatment (ACS, 2015f).
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Transdermal estrogens were evaluated in a pilot study of 12 men with prostate cancer who were being treated with ADT.
In patients with high-risk localised PCa, use a total dose of 76-78 Gy in combination with long-term ADT (2-3 years is recommended).
Using this approach many men can delay or avoid therapy (surgery or radiation) until it is necessary and still be cured.
B) Chemical structure of the non-steroidal antiandrogens flutamide, bicalutamide and nilutamide.
Although intermittent therapy may rely upon restoring a normal testosterone level, it is believed that the testosterone level should be as low as possible when the patient is on treatment, thus generating the lowest serum PSA level possible and likely improving outcome.
Physicians do not always agree about when it is best to start treatment, whether it needs to be continuous or can be stopped and started up again periodically, and whether monotherapy or combination therapy is best.
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Most trials have used 3 months of NAD therapy and have demonstrated a significant decrease in prostate volume by 20-50% and in serum () levels by more than 90%.
There is a definite need to consistently apply scientifically based methodology to the study of erectile function outcomes following prostate cancer treatment.
After about 5-6 months post radiation my libido and erections returned and had almost 5 years of relative ease.
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Overexpression of IL-8 decreases the efficacy of the antiandrogen, bicalutamide, and promotes androgen independent tumor growth.
Loss of sexual drive is not a side effect of brachytherapy and could be caused by a low testosterone level.
Bone mineral density measurements are used to diagnose osteoporosis (a condition marked by decreased bone mass), to see how well osteoporosis treatments are working, and to predict how likely the bones are to break.
The list includes generic names and brand names.
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One investigator assessed the relationship between treatment and adverse events.
Androgen deprivation therapy (ADT) is part of standard therapy for locally advanced or metastatic prostate cancer and is frequently used in men with a rising prostate-specific antigen following radical prostatectomy or radiation therapy.
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Hi Ed, I was sad to hear (and surprised) that your psa had risen after proton therapy.
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Blood samples were taken at each visit and sent to a central laboratory for the determination of serum prostate-spectific antigen (PSA), testosterone, estradiol, LH, FSH, and SHBG levels.
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For prostate cancer patients treated with ADT who experienced a fracture, Oefelein and associates have reported a significantly reduced overall survival.
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The content in this post has not been reviewed by the American Society of Clinical Oncology, Inc.
Neoadjuvant androgen deprivation (NAD) is systemic therapy administered after the diagnosis of prostate cancer but before locoregional therapy such as radical prostatectomy (RP) or radiation.
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