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These events were most often of early onset with peak incidence occurring during the first two weeks of treatment, and transient with a median duration of 16 days.
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The effect is similar to that seen in Parkinson disease.
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As the disease progresses and dopaminergic neurons continue to be lost in the substantia nigra, L-dopa eventually becomes ineffective for treating the motor symptoms and may concurrently cause dyskinesias.
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Madopar (containing 200 mg levodopa and 50 mg benserazide) to six healthy males and six healthy females in a cross-over randomized study with a minimum washout period of 8 days.
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The expected result of DBS is to relieve some or most of the motor dysfunction.
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Most common side effects were hallucinations (20%), dyskinesias (20%), dizziness (8%), and sleepiness (6%).
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Modified- release forms may reduce fluctuations in blood levels and are useful in patients who have been taking levodopa for some time to counteract the 'wearing-off' effect (see 'Longer-term problems' section).
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