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More than half of children were reported to have experienced one or more of: nausea or vomiting after taking MTX, anticipatory nausea, fear of blood tests or fear of injections.

Six months into combination therapy, however, his platelet count began to fall, and it remained low despite a decrease in the dose of methotrexate to 5 mg weekly.

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Methotrexate has also been used to induce miscarriage in ectopic pregnancies.

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At the end of treatment, it should be at very low or undetectable levels in the blood.

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