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Drugs that target different steps of the HIV lifecycle could be especially beneficial for treatment-experienced people with extensive drug resistance.

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Patients with Hepatitis B virus infection may present to the treating clinicians at various stages of natural history of hepatitis B infection, including acute viral hepatitis, chronic active hepatitis, incidental hepatitis B s antigen-positive patients and those with decompensated cirrhosis and hepatocellular carcinoma.

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Twenty-Eight Day Safety and Efficacy of Tenofovir Alafenamide (TAF) Fumarate in Chronic Hepatitis B (CHB) Patients.

Beyerlein said these findings suggest but dont prove that its not just the cumulative number of infections, but also that the timing of infections is quite important as well.

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Overall, there were no serious adverse events, deaths, or treatment discontinuations that could clearly be attributed to adrenal insufficiency.

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Even with clearance of the hepatitis B surface antigen (HBsAg), there is no decrease in the risk of hepatocellular carcinoma if the HBsAg is lost in patients after the age of 50 years.

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Long-term oral carcinogenicity studies of TDF in mice and rats were carried out at exposures up to approximately 10 times (mice) and 4 times (rats) those observed in humans at the recommended dose of TDF (300 mg) for HIV-1 infection.

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