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Cerebrovascular Events and Fatalities with 5HT 1 agonists: Cerebral hemorrhage, subarachnoid hemorrhage, stroke, and other cerebrovascular events have been reported in patients treated with 5-HT 1 agonists; and some have resulted in fatalities.

Another trial found similar results in previous nonresponders to triptans.

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Children younger than 12 years of age should not take triptans.

The suits allege that Forest illegally engaged in off-label promoting of Lexapro for use in children, that the company hid the results of a study showing lack of effectiveness in children, and that the company paid to doctors to induce them to prescribe Lexapro to children.

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Caution should be exercised in patients with history of heart disease, menopause, poor blood supply, ischemic bowel disease, liver or kidney disease, breathing problem, high blood pressure, diabetes, stroke, during pregnancy and breastfeeding.

Zolmitriptan can be used for long term for acute attack migraine with or without aura.

In a clinical study of botulinum toxin type A, patients participating in the 9-month treatment period with three treatments experienced headache frequency decreases up to 50%.

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In 2004, two separate civil suits alleging illegal marketing of citalopram and escitalopram for use by children and teenagers by Forest were initiated by two whistleblowers, one by a practicing physician named Joseph Piacentile, and the other by a Forest salesman named Christopher Gobble.

Secondary headaches are caused by other medical conditions, such as sinusitis, neck injuries or abnormalities, and stroke.

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There are no adequate studies in women for determining infant risk when using this medication during breastfeeding.

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This is a randomized, double-blind, multi-center, parallel group study designed to compare the safety and efficacy of a range of doses of ZP-Zolmitriptan intracutaneous microneedle systems to placebo.

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For many women, withdrawal of antiepileptic drugs before pregnancy results in recurrence or exacerbation of seizures, which can be dangerous for both mother and fetus.

Such headaches are caused by an interaction between blood vessel and nerve abnormalities.

The diseases within the category of PNDs include aromatic L-amino acid decarboxylase deficiency, tyrosine hydroxylase deficiency, GTP cyclohydrolase deficiency (Segawa disease), and succinic semialdehyde dehydrogenase deficiency.

Call your doctor if you need to use zolmitriptan nasal spray to treat more than three headaches in a 1-month period.

Be sure to mention the medications listed in the IMPORTANT WARNING section and any of the following: antihistamines (found in cold and allergy medications); diuretics ('water pills'); buprenorphine (Buprenex, Butrans, in Suboxone, in Zubsolv, others); butorphanol; cyclobenzaprine (Amrix); medications for glaucoma, irritable bowel disease, and urinary problems; lithium (Lithobid); medications for migraine headaches such as almotriptan (Axert), eletriptan (Relpax), frovatriptan (Frova), naratriptan (Amerge), rizatriptan (Maxalt), sumatriptan (Alsuma, Imitrex, in Treximet), and zolmitriptan (Zomig); milnacipran (Savella); mirtazapine (Remeron); nalbuphine; naloxone (Evzio, Narcan, others); pentazocine (Talwin); 5-HT 3 receptor antagonists such as alosetron (Lotronex), dolasetron (Anzemet), granisetron (Kytril), ondansetron (Zofran, Zuplenz), or palonosetron (Aloxi); selective serotonin-reuptake inhibitors such as citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem, in Symbyax), fluvoxamine (Luvox), paroxetine (Brisdelle, Prozac, Pexeva), and sertraline (Zoloft); serotonin and norepinephrine reuptake inhibitors such as duloxetine (Cymbalta), desvenlafaxine (Khedezla, Pristiq), and venlafaxine (Effexor); tramadol (Conzip, Ulltram, in Ultracet), trazodone; or tricyclic antidepressants ('mood elevators') such as amitriptyline, clomipramine (Anafranil), desipramine (Norpramin), doxepin (Silenor), imipramine (Tofranil), nortriptyline (Pamelor), protriptyline (Vivactil), and trimipramine (Surmontil).

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals.

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