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Hepatic impairment: Use with caution in patients with severe hepatic impairment (has not been studied; if coagulopathy presents, IM injection may cause hematoma formation).

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In March 1972, Congress passed the Drug Abuse Office and Treatment Act, with a particular interest in developing "long-lasting, non-addictive, blocking and antagonist drugs or other pharmacological substances for the treatment of heroin addiction.

Disulfiram (Antabuse) does not increase abstinence rates or decrease relapse rates or cravings compared with placebo, and it is not recommended for routine use in primary care.

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Several other patients are on this treatment protocol and appear to be doing well at this time.

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Patients at increased risk may be prescribed modified-release opioid formulations such as AVINZA, but use in such patients necessitates intensive counseling about the risks and proper use of AVINZA along with intensive monitoring for signs of addiction, abuse, and misuse.

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Abstinence from chronic drug use unmasks neuroadaptation in brain function that contributes to an ill-defined feeling of dysphoria, anxiety, or malaise that can only be alleviated by renewed administration of the drug.

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We hypothesized that the likelihood of an opioid-relapse event would be lower, the time to relapse longer, and overall rates of opioid use lower with extended-release naltrexone than with usual treatment.

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Chronic exposure to opioids may be associated with changes to the mu receptor, resulting in the propagation of signal transduction in the absence of an agonist.

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