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Recommendations There is no cure for patients with stage IV NSCLC.
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Analysis was carried out on a flow cytometer (FACScan, Becton Dickinson) using Cell Quest Software.
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She is currently waiting for results for EGFR mutation, in which case she will probably be put on some combination of chemotherapy and IRESSA.
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Therefore, this therapy could represent certain clinical advantages for long-term care of certain patients who did not respond to treatment with BCR-ABL inhibitors.
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Whether this elicits impaired DSB repair and increased radiation susceptibility in vivo is open to question, as phase I studies did not show limiting toxicity of cetuximab in association with radiotherapy against advanced head and neck cancer ().
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EGFR tyrosine kinase inhibitors has been optimized after the discovery of EGFR mutations and heralded the era of molecular targeted therapy in NSCLC.
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These results were supported by a retrospective analysis of another clinical trial, which identified a subgroup of 186 patients with EGFR mutation-positive metastatic NSCLC receiving first-line treatment.
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If the same is true for oral chemotherapy there will be a substantial impact on the provision of health care.
The effect of ZD1839 was cytostatic, but higher doses increased apoptotic cell death, and in combination with cytotoxic drugs, ZD1839 markedly enhanced apoptotic cell death.
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We would expect that your mother will require at least 16 weeks of therapy (8 cycles, like our successful cases - now the longest remission being 6 years).
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