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Because of this, patients are usually instructed to take levothyroxine on an empty stomach 30-60 minutes before food intake to avoid erratic absorption of the hormone.
Can I take levothyroxine at bedtime? Ideally, levothyroxine should be the only medication taken at bedtime. If you must take other medications that must be taken in the evening, consider adjusting the timing of these medications so you take them with dinner, leaving four hours afterward so you can take the levothyroxine at bedtime.

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